Epigenetic regulation in induced orexin neuron
نویسندگان
چکیده
*To whom correspondence should be addressed: Kunio Shiota, Laboratory of Cellular Biochemistry, Department of Animal Resource Sciences/Veterinary Medical Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 1138657, Japan, Tel: +81-3-5841-5472; Fax: +81-3-5841-8189; Email: [email protected]
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Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice.
Orexin/hypocretin neurons have a crucial role in the regulation of sleep and wakefulness. To help determine how these neurons promote wakefulness, we generated transgenic mice in which orexin neurons expressed halorhodopsin (orexin/Halo mice), an orange light-activated neuronal silencer. Slice patch-clamp recordings of orexin neurons that expressed halorhodopsin demonstrated that orange light p...
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